The independent effects of oxygen radical scavengers on canine infarct size. Reduction by superoxide dismutase but not catalase.
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منابع مشابه
The independent effects of oxygen radical scavengers on canine infarct size. Reduction by superoxide dismutase but not catalase.
Previous studies demonstrated a significant reduction of ultimate infarct size in the canine heart by the combined administration of superoxide dismutase plus catalase. This study was performed to assess the independent effects of each enzyme on ultimate infarct size due to ischemia/reperfusion. Dogs received 2-hour infusions of superoxide dismutase, catalase, or albumin (controls) via the left...
متن کاملBRIEF COMMUNICATIONS The Independent Effects of Oxygen Radical Scavengers on Canine Infarct Size Reduction by Superoxide Dismutase but not Catalase
Previous studies demonstrated a significant reduction of ultimate infarct size in the canine heart by the combined administration of superoxide dismutase plus catalase. This study was performed to assess the independent effects of each enzyme on ultimate infarct size due to ischemia/reperfusion. Dogs received 2-hour infusions of superoxide dismutase, catalase, or albumin (controls) via the left...
متن کاملCanine myocardial reperfusion injury. Its reduction by the combined administration of superoxide dismutase and catalase.
Therapy directed against the toxic effects of reactive oxygen species may reduce the final extent of ischemic injury in otherwise viable tissue irreversibly injured by the abrupt reoxygenation of reperfusion. In four groups of dogs, superoxide dismutase plus catalase (groups I-III) or saline (controls) (group IV) was infused into the left atrium. Group I received the infusion for 2 hours, begin...
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BACKGROUND The limiting effect of ischemic preconditioning on infarct size has been reported in canine hearts, which contain considerable amounts of xanthine oxidase, a free radical-producing enzyme. Furthermore, a recent study suggested that free radicals generated during preconditioning may contribute to the cardioprotective effect of preconditioning. The present study examined 1) whether pre...
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The pathophysiology of cold injury was examined by cooling a hind leg of an anesthetized New Zealand white rabbit. A flow probe and a thermocouple were placed in the leg to be cooled to monitor the blood flow and tissue temperature. After baseline measurements, the leg was cooled with a freezing mixture up to 0 degrees C, which was followed by rewarming. The other leg served as control. In the ...
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ژورنال
عنوان ژورنال: Circulation Research
سال: 1985
ISSN: 0009-7330,1524-4571
DOI: 10.1161/01.res.56.6.895